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Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation Article

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Engineering 2024, Volume 32, Issue 1,   Pages 58-69 doi: 10.1016/j.eng.2023.09.019

Abstract:

Hepatocyte nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkheadOur in silico analysis of HNF1A, HNF4A, and FOXA2 binding to the 10 candidate glyco-genes studiedOur previous studies identified HNF1A as a master regulator of fucosylation, glycan branching, and galactosylationshort palindromic repeats/dead Cas9 (CRISPR/dCas9) molecular tool for the downregulation of the HNF1AWe also propose a model showing feedback loops with the mutual activation of HNF1A–FOXA2 and HNF4A

Keywords： regularly interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9)     Epigenetics     Hepatocyte nuclear factor1 alpha (HNF1A)     Hepatocyte nuclear factor 4 alpha (HNF4A)     Forkhead box protein A2 (FOXA2)     N-glycosylation    

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Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 303-308 doi: 10.1007/s11684-009-0060-3

Abstract: on the invasion and the related protein expression of Hela cells and the role of hypoxia inducible factor-1α (HIF-1α) were investigated.The Hela cells were divided into three groups, namely, H (non-transfected Hela cells), H (pGenesil-1empty plasmid-transfected Hela cells), and H (HIF-1α-shRNA plasmid-transfected Hela cells), andwere cultured under hypoxia (1% O) and normoxia for 48h.

Keywords： hypoxia     actin     β     -catenin     E-cadherin     invasion    

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract:

The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediatingRecent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional targetIntriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role inAn understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge

Keywords： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway

LI Yanhua, BI Zhigang

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 79-86 doi: 10.1007/s11684-007-0016-4

Abstract: effects and signaling pathway of ultraviolet-B (UVB) irradiation on the expression of hypoxia-inducible factor1α (HIF-1α) and transferrin receptor (TfR).Expressions of epidermal growth factor receptor (EGFR), phosphor-EGF-R and TfR after UVB irradiationIn contrast, DEC1 (+/+) HaCat cells strongly enhanced TfR and HIF-1?We conclude that UVB induces TfR and HIF-1αexpressions via EGFR/PI3K/AKT/DEC1 signaling pathway.
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Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 100-107 doi: 10.1007/s11684-009-0013-x

Abstract: The aim of this study was to explore the expression of integrin-β1 in different stages of hepatic fibrosisThe expression of integrin-β1, tumor growth factor-β (TGF-β) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in different stages of hepatic fibrosis was detected by using RT-PCR.The expression of integrin-β1, TGF-β and TIMP-1 was determined in each group.The expression of TGF-β and TIMP-1 was consistent with that of integrin-β1 in different stages of hepatic

Keywords： liver fibrosis     integrin-β1     resveratrol     tumor growth factor-β     tissue inhibitor of metalloproteinase-1    

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Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1): A Multifaceted Cell Survival Factor that Review

Tamana Yousof, Jae Hyun Byun, Jack Chen, Richard C. Austin

Engineering 2023, Volume 20, Issue 1,   Pages 9-18 doi: 10.1016/j.eng.2022.05.014

Abstract:

Pleckstrin homology-like domain, family A, member 1 (PHLDA1) is a multifaceted intracellular proteinIn recent years, PHLDA1 has received increased attention due to its association with obesity, fatty liverIn this review, the current knowledge of PHLDA1 gene and protein regulation, localization, andThis review highlights the pro- and anti-apoptotic roles of PHLDA1 that contribute to vast array of metabolic

Keywords： ER-stress     Metabolism     Apoptosis     Cell survival     PHLDA1    

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Inhibition of TNF-alpha secretion from peripheral blood monocular cells by triptolid is associated withTNF-alpha-308 gene polymorphisms in rheumatoid arthritis patients

Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 220-224 doi: 10.1007/s11684-010-0025-6

Abstract: This study examined the inhibitory effect of triptolid (TP) on tumor necrosis factor-α (TNF-αthese patients and treated first with lipopolysaccharides (LPS) and then with different doses of TP (1,The results showed that TNF-α level in the supernatants of TP (1 ng/mL)-treated PBMCs was

Keywords： arthritis     rheumatoid     molonuclear cells     tumor necrosis factor     gene polymorphisms     triptolid    

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DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis

Xiuli Zhang, Zhizhou Xia, Xingyu Lv, Donghe Li, Mingzhu Liu, Ruihong Zhang, Tong Ji, Ping Liu, Ruibao Ren

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 302-312 doi: 10.1007/s11684-021-0851-8

Abstract: DDB1- and CUL4-associated factor 8 (DCAF8) is a WD40 repeat-containing protein, which serves as a substrate

Keywords： Dcaf8     male infertility     spermatogenesis    

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Comprehensive evaluation factor of optoelectronic properties for transparent conductive metallic mesh Research Articles

Yilei Zhang, Jinxuan Cao, Zhengang Lu, Heyan Wang, Jiubin Tan,luzhengang@hit.edu.cn

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 11,   Pages 1532-1540 doi: 10.1631/FITEE.2000690

Abstract: Based on optoelectronic properties, we propose a factor , which is simple in form and can be used toThe evaluation factor can also be extended to evaluate the optoelectronic properties of different kinds

Keywords： 金属网栅；TOPSIS法；熵权法；综合评价因子；透明导电膜    

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Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 148-152 doi: 10.1007/s11684-009-0032-7

Abstract: To investigate the regulation of tumor suppressor XAF1 gene expression in digestive system cancers, westudied XAF1 gene promoter transcription activity and mRNA level in digestive system cancer cell lines) and human embryonic kidney 293 cells [HEK293 cells]) as controls. 1395-bp-promoter fragment of XAF1The expression of XAF1 mRNA in HEK293 and L02 were significantly higher than that in any of the threecell lines may be due to loss of transcription activity of XAF1 promoter.

Keywords： gene     X-linked inhibitor of apoptosis protein associated factor-1 (XAF1)     promoter     transcription regulation    

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carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 476-492 doi: 10.1007/s11684-022-0966-6

Abstract: knockdown yielded opposite results. 5′-tiRNA-Gln exerted its function by binding eukaryotic initiation factor4A-I (EIF4A1), which unwinds complex RNA secondary structures during translation initiation, causingThe suppressed downregulated proteins include ARAF, MEK1/2 and STAT3, causing the impaired signalingof forming intramolecular G-quadruplex structure is crucial for 5′-tiRNA-Gln to strongly bind EIF4A1Clinically, 5′-tiRNA-Gln expression level is negatively correlated with ARAF, MEK1/2, and STAT3 in HCC

Keywords： EIF4A1     G-quadruplex     hepatocellular carcinoma     tRNA-derived small RNA     translation initiation    

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Effect of levonorgestrel intrauterine system on IGF-1 and the dependablity study of prevention pelvic

Wu Xiaojie,Liu Xia,Tao Yueping,Wang Jie

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 4-7

Abstract:

Objective: To study the effect of levonorgestrel Intrauterine System on insulin-like growth factor-l(IGF-1) and the result of levonorgestrel Intrauterine System Prevention pelvic inflammatory disease.The IGF-1 expression of endometrial biopsy specimens during intraoperative and rechected after 6 monthsIntraoperative specimens compared with afteroperation specimens of the IGF-1 expression, there was adisease and inhibition endometrium that Levonorgestrel intrauterine system can prevent endometrial IGF-1

Keywords： levonorgestrel     Intrauterine system insulin-like growth factor-1     pelvic inflammatory disease    

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Analysis of GM（1，1）Model and Its Application in Fire Risk Prediction

Chen Zijin,Wang Fuliang,Lu Shouxiang

Strategic Study of CAE 2007, Volume 9, Issue 5,   Pages 91-94

Abstract:

Theoretical analysis of grey prediction model GM(1, 1) is present inMonotonicity of predicted value and its variation tendency predicted by GM(1, 1)model is proved.the monotonicity of predicted value and its variation tendency,  applicability criterion of GM(1,1) is brought forward.

Keywords： fire forecast     GM(1     1)     rate of the fire injured    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine   Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapyBlockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers,generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4, PD-1,and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies co-targeting

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic    

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geological recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-1

Deng Yunhua

Strategic Study of CAE 2011, Volume 13, Issue 10,   Pages 13-18

Abstract: Moreover, the dominative factor for Dongying is migration and the one for Shahejie is reservoir.According to this guidance, such giant oilfield JX1-1 was discovered with 150 million reserves in the

Keywords： Bohai Liaodong zone     JX1-1     geological recognition     large oilfield    

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Title Author Date Type Operation

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Journal Article

Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Journal Article

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Journal Article

Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway

LI Yanhua, BI Zhigang

Journal Article

Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Journal Article

Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1): A Multifaceted Cell Survival Factor that

Tamana Yousof, Jae Hyun Byun, Jack Chen, Richard C. Austin

Journal Article

Inhibition of TNF-alpha secretion from peripheral blood monocular cells by triptolid is associated withTNF-alpha-308 gene polymorphisms in rheumatoid arthritis patients

Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,

Journal Article

DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis

Xiuli Zhang, Zhizhou Xia, Xingyu Lv, Donghe Li, Mingzhu Liu, Ruihong Zhang, Tong Ji, Ping Liu, Ruibao Ren

Journal Article

Comprehensive evaluation factor of optoelectronic properties for transparent conductive metallic mesh

Yilei Zhang, Jinxuan Cao, Zhengang Lu, Heyan Wang, Jiubin Tan,luzhengang@hit.edu.cn

Journal Article

Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Journal Article

carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor

Journal Article

Effect of levonorgestrel intrauterine system on IGF-1 and the dependablity study of prevention pelvic

Wu Xiaojie,Liu Xia,Tao Yueping,Wang Jie

Journal Article

Analysis of GM（1，1）Model and Its Application in Fire Risk Prediction

Chen Zijin,Wang Fuliang,Lu Shouxiang

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

geological recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-1

Deng Yunhua

Journal Article